Staff Detail

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Leslie R. Morse, DO

Physiatrist

Clinical Instructor, Harvard Medical School

Education:	DO, University of New England College of Osteopathic Medicine, 2001
Residency:	Internship: NH Dartmouth Family Practice, Concord Hospital, NH, 2001-2002 Residency: Boston Medical Center, Physical Medicine & Rehabilitation, 2002-2005
Research Interests:	Osteoporosis; Musculoskeletal medicine; Electrodiagnostic studies

Research & Publications

Grants

2008-2010: Bone Density and Circulating Mediators of Bone Metabolism in Chronic SCI

NIH/NICHD R21 HD057030A PI

The goals of this project are to determine the effect of injury level and severity on bone mineral density (BMD) at non-traditional skeletal sites (distal femur and proximal tibia) in chronic SCI and to determine the relationship between bone mineral density (BMD) at the distal femur and proximal tibia, markers of bone turnover, and circulating levels of the RANKL/OPG pathway.

2009-2010: Bone Density and Circulating Mediators of Bone Metabolism in Chronic SCI

NIH/NICHD 3R21HD057030-02S1

The goals of this project are to (1) assess longitudinal change in BMD in 40 persons with chronic SCI and 10 able-bodied persons previously studied in year 1 of the parent grant, (2) assess the relationship between regional fat distribution and longitudinal change per year in BMD, and (3) assess the relationship between circulating levels of adipose derived hormones (leptin, adiponectin, Interleukin-6 (IL-6), and Tumor Necrosis Factor) with loss of BMD at the distal femur and proximal tibia, and (4) use microarray technology to compare gene expression profiles of circulating osteoclast precursors to identify metabolic pathways and specific genes modulating ongoing bone loss in chronic SCI.

Publications

1. Morse L, Chen D, Franklin D, Xiong Y, Chen-Kiang S. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18 and IL-6. Immunity 1997; 6:47-56.

2. Burke DT, Hoberman C, Morse LR, Pina B. A new procedure for gastrostomy tube replacement verification: A case report. Arch Phys Med Rehab 2005; 86:1484-1486.

3. Schinchuk L, Morse L, Huanchahuari N, Arum S, Chen T, Holick M. Vitamin D deficiency and metabolic bone disease in rehabilitation inpatients. Arch Phys Med Rehabil 2006; 87:904-908.

4. Pham L, Purcell P, Morse L, Stashenko P, Battaglino RA. Expression analysis of nha-oc/NHA2: a novel osteoclast-specific gene. Gene Expr Patterns 2007; 7:846-851.

5. Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren P, Sasaki H, Stashenko P. NHA-oc/NHA2: a mitochondrial cation-proton Antiporter selectively expressed in osteoclasts. Bone 2008;42:180-192.

6. Morse LR, Stolzmann K , Nguyen H, Jain N, Zayac C, Gagnon D, Tun C, Garshick E. Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury. Arch Phys Med Rehab 2008;89:726-731.

7. Morse LR, Nyugen H, Jain N, Williams W, Tun C, Battaglino R, Stashenko P, Garshick E. Age and motor score predict osteoprotegerin levels in chronic SCI. J of Musculoskeletal Interactions 2008; 8:50-57.

8. Morse L, Teng Y, Newton K, Du Y, Liao W, Kohler T, Mueller R, Graves D, Stashenko P, Battaglino RA. Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats. Osteoporos Int 2008; 19:645-652.

9. Morse LR, Stolzmann K, Hallett L, Waddimba A, Gagnon D, Lazzari A, Garshick E. Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int 2009; 20:385-392.

10. Morse LR, Geller A, Stolzmann K, Matthess K, Lazzari A, Garshick E. Barriers to providing dual energy X-ray absorptiometry services to individuals with spinal cord injury. Am J Phys Med Rehabil 2009; 88:57-60.

11. Morse LR, Giangregori L, Battaglino RA, Holland R, Craven BC, Stolzmann K, Lazzari A, Sabharwal S, Garshick E. VA based survey of osteoporosis management in spinal cord injury. PM&R 2009; 1:240-244.

12. Morse LR, Lazzari A, Battaglino RA, Stolzmann K, Matthess K, Gagnon D, Davis S, Garshick E. Dual energy X-Ray absorptiometry of the distal femur may be more reliable than the proximal tibia in spinal cord injury. Arch Phys Med Rehabil 2009; 90:827-831.

13. Xu Y, Young M, Battaglino RA, Morse LR, Fontana CR, Pagonis TC, Kent R, Stashenko P, Soukos NS. Endodontic antiomicrobial photodynamic therapy: Assessment of safety on fibroblasts and osteoblasts in vitro. J Endod. 2009 Nov;35(11):1567-72.

14. Xu Y*, Morse LR*, da Silva R, Odgren PR, Sasaki H, Stashenko P, Battaglino RA. PAMM: A redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal 2009; [Epub ahead of print].