Effects of Amantadine on the Treatment of Chronic TBI Irritability and Aggression
Purpose: To investigate whether the drug amantadine is effective in treating irritability and aggression in patients with TBI.
To Qualify: 1. 18-65 years old
2. TBI>6 months ago
3. Experience irritability and aggression following TBI
Exclusions: 1. Penetrating head injury
2. Use of amantadine within the past month
Length: 3 months
Study Visits: 1. 3 total visits, 3 hours each
2. 1 screening or baseline visit
3. 2 follow-up visits at 28 days and 60 days.
Effects of Light Emitting Diodes on Memory in TBI Patients
Purpose: To investigate whether Light Emitting Diodes can improve working memory in TBI patients
To qualify: 1. 18-65 years old
2. Mild TBI>6 months ago
3. Experience memory and thinking issues following TBI
Exclusions: 1. Penetrating head injury
2. Moderate to severe TBI
Length: 4 months
Study Visits: 1. 23 Total
2. 2 screening visits
3. 3 LED treatments per week for 6 weeks
3. 3 follow-up visits - 1 week, 1 month and 2 months after study completion
Effect of Zolpidem on Restoration of Consciousness Following TBI
Purpose: To investigate whether the drug zolpidem can restore consciousness in patients with TBI
To Qualify: 1. Age 18+
2. TBI>4 months ago
3. Vegetative or minimally conscious state
Exclusions: 1. Ventilator dependency
2. Previous use of zolpidem for restoration of consciousness
Study Visits: 1. Phase I: 2 days at home
2. Phase II: 2 days at Spaulding Boston
3. Phase III: 3 days Moss Rehab
*Only qualifying patients may participate in Phase II and III.
For more information or to see if you might qualify, please call Laura Burns, MBA - TBI research Enrollment Coordinator at 617-573-2237.
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