Long-term Assessment and Treatment Exploration for TBI (LATE-TBI) Lab

Welcome to the LATE-TBI Lab

The LATE-TBI Lab is dedicated to researching the long-term effects of traumatic brain injury (TBI), including chronic and neurodegenerative diseases, such as chronic traumatic encephalopathy (CTE) and amyotrophic lateral sclerosis (ALS). Our work aims to bridge the gap between bench and bedside, with the ultimate goal of developing effective treatments for TBI associated disease. We aim to identify novel diagnostic strategies and therapeutic targets to improve the lives of individuals affected by CTE, ALS, and related conditions.

About Us

The LATE-TBI Lab is dedicated to identifying innovative ways to improve recovery and quality of life for individuals experiencing the chronic and progressive changes following traumatic brain injury (TBI). Prior research has identified the risk factors associated with neurodegenerative disease following TBI, and sought to improve the clinical diagnosis of these diseases.

About Daniel H. Daneshvar, MD, PhD

Chief | Division of Brain Injury Rehabilitation
Vice President of Medical Staff | Spaulding Rehabilitation
Director of Training | Rehabilitation Outcomes Center at Spaulding

Dr. Daneshvar conducts research on the long-term effects of moderate-severe traumatic brain injury, concussion, and repetitive head impacts, including chronic traumatic encephalopathy (CTE) and amyotrophic lateral sclerosis. Dr. Daneshvar has authored and co-authored over 70 scientific papers including in JAMA, Nature Communications, and Brain, and his work has been featured broadly including in the New York Times, the Wall Street Journal, NPR, and ESPN.

He also founded Team Up Against Concussions, the first scientifically validated concussion education program for kids, for which he received the 2016 Excellence in Public Health award from the United States Public Health Services. He is the Director of the Institute for Brain Research and Innovation at TeachAids, which created CrashCourse: a free, scientifically validated virtual reality and computer-based concussion education program, for which he received the 2021 Dean’s Community Service Award from Harvard Medical School.

Dr. Daneshvar received his SB from the Massachusetts Institute of Technology, and completed his MD/PhD at the Boston University CTE Center, where his research resulted in the first dissertation in history to study CTE. He completed residency at Stanford University before joining the faculty at Harvard Medical School.

Published Research

View the most up-to-date list of publications on PubMed

Highlights

• Daneshvar DH, Nair ES, Baucom ZH, Rasch A, Abdolmohammadi B, Uretsky M, Saltiel N, Shah A, Jarnagin J, Baugh CM, Martin BM, Palmisano JN, Cherry JD, Alvarez VE, Huber BR, Weuve J, Nowinski CJ, Cantu RC, Zafonte RD, Dwyer B, Crary JF, Goldstein LE, Kowall NW, Katz DI, Stern RA, Tripodis Y, Stein TD, McClean MD, Alosco ML, McKee AC, Mez J. Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males. Nat Commun. 2023 Jun 20;14(1):3470. doi: 10.1038/s41467-023-39183-0. PubMed PMID: 37340004; PubMed Central PMCID: PMC10281995.
• McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH. Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. Acta Neuropathol. 2023 Apr;145(4):371-394. doi: 10.1007/s00401-023-02540-w. Epub 2023 Feb 10. Review. PubMed PMID: 36759368; PubMed Central PMCID: PMC10020327.
• Daneshvar DH, Mez J, Alosco ML, Baucom ZH, Mahar I, Baugh CM, Valle JP, Weuve J, Paganoni S, Cantu RC, Zafonte RD, Stern RA, Stein TD, Tripodis Y, Nowinski CJ, McKee AC. Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes. JAMA Netw Open. 2021 Dec 1;4(12):e2138801. doi: 10.1001/jamanetworkopen.2021.38801. PubMed PMID: 34910152; PubMed Central PMCID: PMC8674746.
• Daneshvar DH, Yutsis M, Baugh CM, Pea RD, Goldman S, Grant GA, Ghajar J, Sanders LM, Chen CL, Tenekedjieva LT, Gurrapu S, Zafonte R, Sorcar P. Evaluating the Effect of Concussion-Education Programs on Intent to Report Concussion in High School Football. J Athl Train. 2021 Nov 1;56(11):1197-1208. doi: 10.4085/509-20. PubMed PMID: 33428746; PubMed Central PMCID: PMC8582631.
• Mez J,* Daneshvar DH,* Kiernan PT,* Abdolmohammadi B, Alvarez VE, Huber BR, Alosco ML, Solomon TM, Nowinski CJ, McHale L, Cormier KA, Kubilus CA, Martin BM, Murphy L, Baugh CM, Montenigro PH, Chaisson CE, Tripodis Y, Kowall NW, Weuve J, McClean MD, Cantu RC, Goldstein LE, Katz DI, Stern RA, Stein TD, McKee AC. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017 Jul 25;318(4):360-370. doi: 10.1001/jama.2017.8334. PubMed PMID: 28742910; PubMed Central PMCID: PMC5807097. *co-lead authors